Best@BUCHI #57: Laboratory Scale Spray Drying of Lactose

Lab Scale Spray Drying of Lactose Study

Lab Scale Spray Drying of Lactose

Spray drying is a commonly practiced method to prepare inhalable powders. This study reviews recently published scientific work in the field of lactose spray drying for inhalable applications using Buchi laboratory scale spray dryers. The generations of the Mini Spray Dryer; B-190, B-191 and B-290 models and the new Nano Spray Dryer B-90 are included in the study.

Please contact Buchi for more information on our laboratory scale spray dryers and to download this study.

Spray drying has been applied to a variety of substances, such as peptides, antibiotics, vaccines and biodegradable carrier particles.
The described delivery technology can be used for lung-specific applications to treat cystic fibrosis, asthma, chronic pulmonary infections, lung cancer or tuberculosis.

Lactose is one the most common excipients used for dry powder lung delivery and is approved by the Food and Drug Administration (FDA) for pulmonary delivery, and so, widely applied in aerosolization. This is due to its non-toxic, readily degradable properties after administration. Lactose also has the advantageous material property of a low stickiness behaviour compared to other sugars.

The conclusions include that spray drying is able to produce stable, efficient and inhalable dry lactose powder systems for respiratory delivery with adequate particle size and shape for deep lung deposition.

The Nano Spray Dryer B-90 provides a novel spray drying technique in laboratory scale to prepare submicron particles for pulmonary delivery dry powder formulations.

BÜCHI Labortechnik AG thanks all scientists listed in the references of the study for the remarkable research carried out on BÜCHI spray dryers.