NEW Product Announcement

Introducing the new BUCHI Rotavapor® R-300 platform

The new Rotavapor® R-300 from BÜCHI Labortechnik AG, the global leader in rotary evaporators, introduces ground-breaking innovations for laboratory rotary evaporation. Asked about the main benefit to users of the new rotary evaporation system, Dr Rudolf Hartmann, Evaporation Group Manager at BUCHI, says,

BUCHI Rotavapor R-300 lres “In many laboratories, the evaporation of solvents takes up a lot of time that they would prefer to spend on more complex tasks. So we looked for a way to relieve users of the routine work while keeping them up to date with the status of the process.”



BUCHI also wanted to design the new Rotavapor® so that clients did not have to choose between different models but instead could individually configure a versatile product that suits their own specific requirements while also being adaptable to changing circumstances at any time, Hartmann expands.

Modular platform concept

BUCHI’s innovative solution is based on a flexible, modular platform that can be easily adapted to individual needs ranging from a simple manually operated rotary evaporator to a fully automated system.

  • The lift for raising and lowering the evaporating flask is available in electronic and manual versions.
  • The heating bath is available in versions designed for a 1or 5 liter flask. While the smaller heating bath impresses with its rapid heating time (4 min to 50°C), the larger version is distinguished by its higher achievable temperatures (up to 220°C).
  • The rotary evaporator features an integral display on the heating bath base that shows rotation speed, bath temperature and lift position. The device can, however, be operated with either of two control panels, the Interface I-300 or I-300 Pro, which act as central control units.

Integrated unit: centralized control

I-300 and I-300Pro“By ‘centralized control’ we mean the control of all process parameters such as heating bath, vapor and coolant temperature, rotation speed and system pressure,” explains Dr Daniel Meier, head of the development lab at BUCHI. “For users it is decisively important to have all parameter data available in one place rather than having to check three different displays to make sure everything is working properly.” Depending on the user’s preference, the display can be mounted either on the rotary evaporator or on the vacuum pump, or even on the laboratory wall using a special mount. It is also possible to operate a rotary evaporator with two interface units. So, for example, one interface unit could be mounted on the rotary evaporator inside a fume hood and another outside the fume hood. With the benefit of bidirectional communication, an operation can be carried out from either interface unit at any time. In addition, quick manual adjustments of rotation speed, heating bath temperature and coolant temperature can be made at any time by means of the control knobs.

Methods and BUCHI Cloud: ways to automate and monitor processes

“So for the first time, completely unattended operation is possible”

Probably the most important innovation is what lies behind the “Methods” functionality. A new feature of the Interface I-300 Pro is the facility to automate routine processes. “For customers who follow standard operating procedures (SOPs), this represents significant added value,” says Bernie Hertz, rotary evaporation product manager at BUCHI. “A method typically consists of four stages: evaporation, draining off distillate, drying the substance and venting the system. The sequence can be precisely defined and the interface unit controls every step automatically,” continues Hertz. If manual intervention is necessary, the user can be notified by push message on a smartphone.

Push-message notification is made possible by the new BUCHI Cloud Solution. That involves connecting the Interface I-300 or I-300 Pro via LAN to the company network. The connection to a smartphone or tablet is established via the BUCHI Cloud. The BUCHI Rotavapor® mobile app shows the current specified settings and actual readings – as they would be displayed on the interface unit. If the mobile device is connected to an I-300 Pro, even progression graphs can be displayed. What is more, any number of Rotavapor® R-300 units can be connected via the Rotavapor® app.

Automatic distillation – even of foaming samples

Unattended operation can be achieved not only with the aid of definable methods but also by means of the AutoDest function, as the automatic distillation mode is known. AutoDest is based on a new method of operation. The vacuum is automatically regulated on the basis of the difference between the inlet and outlet temperature on the condenser and the change in the vapor temperature. That enables uncomplicated automatic distillation even of complex formulations.

Simplicity of operation the prime consideration

“User-friendliness was given prime importance in the development process,”

Rotavapor with woman holding iphone“Countless user trials have meant that not only is the interface intuitive but also key mechanical components such as the handle for adjusting lift position or the Combi-clip for easy attachment of evaporating flasks are perfectly adapted to users’ needs” reports Matthias Wagner, Project Manager.

Like the preceding Rotavapor® R-210 and R-215 models, the R-300 is available with a choice of seven different condensers. As well as coil condensers or dry-ice condensers, there are glass apparatuses specially suited to reflux reactions, Soxhlet extraction or highly foaming samples.

V-300: the noiseless vacuum source

Along with the Rotavapor® R-300, the new Vacuum Pump V-300 has also been introduced. As well as integrating perfectly into the rotary evaporator system with central control via the Interface I-300 or I-300 Pro, the pump impresses with its super-silent operation. Benefiting from modified speed-controlled operation compared with its predecessor, the unit’s noise output in normal operation is a hardly audible 32 dB.

With a flow rate of 1.8 m3/h and a terminal vacuum of 5 mbar, the V-300 is ideally suited to distillation in combination with a rotary evaporator. And with its transparent front, potential particle contamination can be immediately detected.

Eco-friendly condensation

F-105The Rotavapor® R-300 system is completed by the recirculating chiller F-305, F-308 or F-314, depending on the cooling capacity required. Just like the vacuum pump, the recirculating chiller fits perfectly into the overall system and can be easily operated from the I-300 or I-300 Pro central interface unit. And here too, rapid intervention using the navigation control on the chiller display is possible at any time. The optional temperature lock makes sure that the temperature is not inadvertently changed. Thus bidirectional communication features throughout the evaporation system.

The optional ECO mode guarantees economical operation by switching the chiller to an energy-saving standby mode after a defined period but also enables the desired temperature to be reached again in a short time.

>> See full product offering


Separation of cannabinoids for clinical use

PrepChrom C-700: Isolation of cannabidiol (CBD) and tetrahydrocannabinol (THC) from other cannabinoids extracted from cannabis

PrepChrom WordPressThe separation of cannabinoids is an important process which is necessary for clinical studies. The aim of these studies is to investigate the effect of the isolated cannabinoids on patients suffering from chronic illnesses and side effects caused by chemotherapy. The relaxation of laws concerning medical use of cannabis all around the world, especially the United States, has increased the interest in determining the effect of cannabinoids on the human body. Clinical studies require large amount of highly pure separated cannabnnoids. This can easily be achieved with the PrepChrom C-700.


Cannabis is an extremely versatile plant and has been used for many purposes throughout history. Some specific sorts are used for fibers in the textile and paper industry because of their long stems. It is a useful source of foodstuffs, such as hemp oil and seed. Due to the cannabinoids, cannabis is also a popular recreational drug. These substances can cause mental and physical effects when consumed. The impact of the cannabinoids on the human body is of great interest for the pharmaceutical sector. The research emphasis lies in treating the side effects of chemotherapy, inflammatory diseases like multiple sclerosis or degenerative illnesses such as Parkinson’s disease.[3] AI FAME GmbH, a Swiss company, is a pioneering company to extract the plant-based active substances and make them water-soluble for improved, further processing.

Here, we aim to separate three cannabinoids, i.e. cannabidiol, tetrahydrocannabinol and tetrahydrocannabinolic acid in high purity from the extract.


Equipment: PrepChrom C-700

Sample: Water-soluble cannabis extract. Cultivated, extracted and provided by AI FAME GmbH

Preparation: The chromatographic separation is performed with 1 mL of the water-soluble cannabis extract diluted in 1 mL methanol : water (1:1)

Separation: Method parameters
Column:  Sepacore® C-18 80 g
Particle size:  40-63 μm
Flow rate:  40 mL/min
Sample loop:  2 mL
Detection:  253, 270 nm and SCAN 200-600 nm

Gradient: methanol (A) : water(B)
50 % – 90 % methanol (A) in 20 min
90 % – 90 % methanol (A) in 10 min
90 % – 95 % methanol (A) in 5 min
95 % – 95 % methanol (A) in 10 min


Cannabidiol (CBD) bearing a 1,3-diol functional group on its benzene ring, is the first substance to be eluted when applying reversed phase conditions (Figure 1), hence, is the most polar cannabinoid in the sample. The second compound, eluting after 27 minutes, is tetrahydrocannabinol (THC). The last substance to be eluted is tetrahydrocannabinolic acid (THCA), a form of cannabinoid which easily decarboxilates in to THC when exposed to light or heat. Assignment of the signals and identification was done by comparison with reference HPLC data provided by AI FAME GmbH.

Cannabinoide SN finalFigure 1: Methanol : water separation of the extracted cannabinoids using the PrepChrom C-700. Detection at 270 nm, 254 nm, and 200-600 nm SCAN.




The three cannabinoids extracted by AI FAME GmbH could easily be separated and separately collected with the PrepChrom C-700.

The water-solubility of the extract enables the use of aqueous solvents that have inherent economic and ecologic advantages over common organic solvents.

The growing interest in the clinical use of cannabinoids is unbreakable. Furthermore, cannabis is decriminalized and it is allowed to exploit the potential of its valuable substances. BUCHI offers straight forward solutions to separate and purify small to large size batches of the precious extracts.


AI FAME GmbH, Switzerland, is thanked for providing the extract and for the fruitful analytical discussion.


[1] Sutton, IR. Daeniken, P. (2006). Cannabinoids in the management of intractable chemotherapy-induced nausea and vomiting and cancer-related pain. The Journal of Supportive Oncology.

[2] State Medical Marijuana Laws. National Conference of State Legislatures. (16.3.2015).

[3] Kogan, NM. Mechoulam, R. (2007) Cannabinoids in health and disease. Dialogues Clin Neurosci. 2007 Dec; 9(4): 413–430.

>> See additional Application Notes

Live Webinar: Industrial Rotavapors® – The next generation in waste solvent management & recycling

Industrial_312225-1330b email

Wednesday, June 17, 2105 I 2:00pm Eastern Time

The cost of solvent disposal can be just as high or higher than the cost of purchasing solvent. Less expensive technical grade solvent can be purified by distillation to achieve the purity necessary for academic and industrial applications. Solvent reclamation, recycling and purification with a BUCHI Industrial Rotavapor is not only efficient but it pays for itself after one year. Join us to discover ways to better manage or develop your own in-house solvent disposal/recycling program and the benefits of this type of program.

During this webinar you will:

  • Solutions to improve the purity of technical grade solvents
  • Solvent reclamation and reselling
  • Solvent recycling

Who should attend:

  • Industries: Academia, Pharmaceutical, Chemical, Environmental
  • Job titles: Lab Managers, Chemical Engineers, Grad Students, Research Assistants, environmental health and safety staff

Click to register

Live Webinar: Microencapsulation – an overview of the technology


Wednesday, June 10, 2105 I 2:00pm Eastern Time

Discover more about the reliable and versatile solutions offered by spray drying and encapsulation. This webinar will provide you with a complete overview of microencapsulation using the two technologies, from matrix encapsulation to core and shell capsule formation.

During this webinar you will:

  • Fundamentals of microencapsulation and types of materials used in spray drying versus prilling by vibration
  • Cells, probiotic foods, and pharmaceutical applications
  • Release mechanisms and profiles of the encapsulated materials

Who should attend:

  • Industries: Academia, Pharmaceutical, Food & Beverage
  • Job titles: Flavor Chemist, Principle Investigator, Professor, R&D Scientist

Click to register

NEW Product Announcement

Introducing the new BUCHI Rotavapor® R-100 System

With the launch of Rotavapor® R-100 Essential, BÜCHI Labortechnik AG, the world leader in rotary evaporation, presents an economical, complete system for fundamental laboratory applications using high quality BUCHI parts.

R-100_V-100_I-100_F-105_314205-1331“Dedicated discussions with our customers, globally, demonstrated the desire in the market for an economical solution that meets the essential needs in evaporation. Ideally this should be achieved by products that are integrated within a complete system,” says Dr. Ruedi Hartmann, Product Group Manager for Evaporation.

The new BUCHI Rotavapor meets these needs in a way that is unique to this segment. The complete solution, consists of the individual products: Rotavapor® R-100, Vacuum Pump V-100, Interface I-100 and an optional Recirculating Chiller F-100/105. The interface I-100 serves as a central control unit, allowing you to switching the vacuum pump and recirculating chiller on/off.

Customer benefits of the entire Rotavapor® Essential solution are diverse:

  • Economical pricing
  • Efficient operation due to the optimal interaction of all components
  • Convenient and flexible handling of the digital vacuum control
  • Minimized solvent emissions due to optimized process parameters
  • Enhanced safety ensured by (optional) coated glassware and safety shield
  • Suitable for a variety of applications thanks to multiple flasks of various sizes, including a bump trap

The complete solution offers a significant price advantage compared to the individual products and can be ordered conveniently with a single order code.

>> See full product offering

EPA compliant sample preparation for environmental analysis

Current regulatory developments in the US market have led to increased use of the BUCHI Syncore in contract labs

Environmental_landscape lr

Industrialization, globalization, economic growth and an expanding green conscience demand a qualitative and quantitative leap in environmental protection and analysis. This development is widely supported, globally accepted, and increasingly impacts local as well as global regulation and law. Numerous countries have implemented strict regulations or have tightened their demand for an environmentally sustainable economy during recent years.

One of the latest and most prominent examples for tightened legislation is the United States Environmental Protection Agency (US EPA). The US EPA has not only lowered the threshold values for numerous harmful emissions for both industry and research, but has also started to tightly regulate laboratories responsible for testing such emissions. This has created quite a significant environmental testing industry, mostly consisting of customer contract laboratories specialized in testing various environmental samples in accordance to US EPA regulations. Recent news from several US states indicate that the agency has started to enforce those regulations and closely monitor affected institutions. This has already led to several substantial and publicly released monetary fines in 2014. The main point of interest of the US EPA is the organic solvent balance of affected companies. Solvents purchased and used by companies must be accounted for upon disposal, discrepancies are attributed to loss of solvent to the atmosphere. Among other factors, organic solvent emissions are a critical influence on air pollution and the greenhouse effect. Companies which fail to verify their solvent turnover are subject to further EPA investigations.

This situation becomes important once contract labs have reached a certain size. With dozens or hundreds of mandatory solvent exchanges and evaporations every day, the solvent emission factor becomes a serious aspect for every company in this segment.

For more than 75 years the family owned Swiss company, BÜCHI Labortechnik AG, has been known as a leading provider for solutions in rotary and parallel evaporation. Sustainability is one of BUCHI’s core values, a creed that has resulted in many environmentally friendly innovations and products which aim to conserve energy and water resulting in the smallest possible impact on the environment. One such product is the Syncore® Analyst, a highly productive parallel evaporator combined with the latest SVR (solvent vapor recovery system) technology, which allows simultaneous drying or concentration of up to 12 samples to a pre-defined residual volume at low temperatures while applying gentle vacuum conditions.

The Syncore® is tailored to the demands of modern high-throughput environmental laboratories. High analyte recoveries, even of sensitive compounds such as SVOCs, are obtained by means of a chilled zone at the bottom of each sample vessel. When used in combination with the programmable BUCHI vacuum controller and the individual sample sealing work quality is increased by automating processes to produce reproducible results and eliminate the chance of samples going to dryness or being cross-contaminated. High analyte recoveries are further obtained using a chilled Flushback module. The Flushback module partially condenses the solvent vapor at the top part of the sample vessel generating a continuous rinsing along the glass wall. Thus, adsorption of analytes at the glass wall is avoided.

The solvent vapor is condensed at the primary condenser and collected, a post-pump secondary condenser makes sure no solvent vapors escape the evaporation system. As a result, solvent recoveries greater than 95% are achieved. This not only eliminates harmful solvent emissions inside the laboratory, it is also beneficial to the environment and saves money as the recovered solvent can be reused.

Automated parallel sample concentration with high analyte and solvent recovery is achieved with the Syncore® Analyst. The Syncore® technology reduces manual labor and is fully compliant with the latest amendments to the regulations by the US EPA Solvent Emission Program, yielding solvent recoveries greater than 95%.

Current regulatory developments in the US market have therefore led to increased use of the BUCHI Syncore in these contract labs. This increased popularity of the Syncore not only proves that the combination of fast parallel evaporation, low cost per sample, and high solvent recovery is unrivaled, but also that the instrument is fully compliant with the latest emission regulations.

>> Find out more

Voice of the customer:
“If you’re looking to take your laboratory to a better level of quality, efficiency, and environmental friendliness, the Syncore Analyst is the way to go”
>> Download Case Study

Lionel Thomas, Laboratory Manager,
Accutest Laboratories, NJ

Solutions for alcoholic beverages

From raw material to the drinks you taste

Different alcoholic drinksIn this modern, digital world consumer product experiences are rapidly communicated to a global audience. More than ever before, the value of a brand is reflected in the quality and consistency of every single product introduced into the marketplace despite the possible variation in the raw material quality or the production process. The production of alcoholic beverages with consistent taste and quality requires experience and quality control at all stages of production, from raw material inspection to final product analysis.

BUCHI understands how to assist the manufacturers of alcoholic beverages in meeting your goals and offers solutions for the entire production cycle.

Production cycle step Sample matrix Analyte Analysis technology
Raw material e.g. barley, hops, grapes Moisture, protein, nitrogen, alpha and beta bitter acid, storage index NIRSolutions
Malting, fermentation,
wine pressing,
Malt, grains Total nitrogen, soluble nitrogen, moisture, acid, alcohol, starch NIRSolutions
Final product Wine, beer, spirits Alcohol, ethyl carbamate, volatile acids, sulfur dioxide, protein Steam distillation, Kjeldahl,
solid phase extraction (SPE)

For more than 50 years, BUCHI has been developing ingenious solutions for direct steam distillation and Kjeldahl applications. Our solutions include innovative products for the entire process workflow, customized application support, practical apps, and professional maintenance. Tailor-made hardware, software support, and precalibrations underpin the NIRSolutions concept.

Explore BUCHI’s solutions covering

  • the broadest range of applications for steam distillation (alcohol, SO2, volatile acids, protein)
  • more than 50 years of experience in protein determination according to Kjeldahl
  • combined parallel solid phase extraction (SPE) and parallel evaporation for the determination of ethyl carbamate
  • the multi-component quality check of raw materials and final products applying the NIR technology
  • the real-time in-line process monitoring enabled by NIR, VIS and camera sensors

By collaborating closely with our customers, we do everything in our power to make our products, systems, solutions, applications and services as sustainable as possible for people and the environment.

>> Find out more

Voice of the customer:
“The solution for Kjeldahl as well as sulfur dioxide determination in one single instrument is excellent. Moreover the support for application development is very much appreciated.”

Dr. S.S. Marwaha, Chief Executive Officer,
Punjab Biotechnology Incubator, India.